Research Journal of Pharmaceutical Dosage Form and Technology

Anilkumar J. Shinde ¹, Harinath N. More ²

Affiliations
1 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur. (M.S) Pin-4160 13, IN
2 Bharati Vidyapeeth College of Pharmacy, Kolhapur. (M.S) Pin-4160 13, IN

Abstract

The challenge of modern drug therapy is the optimization of the pharmacological action of drugs coupled with the reduction of their toxic side effects in vivo. On response is the use of colloidal drug carriers that can provide site specific or targeted drug delivery combined with optimal drug release profiles.^1,2 With the advent of nanotechnology, the prospects for using engineered nanomaterials with diameters of < 100 nm in industrial applications, medical imaging, disease diagnosis, drug delivery, cancer treatment, gene therapy and other areas have progressed rapidly. The potential for nanoparticles (NPs) in these areas is infinite, with novel applications constantly being explored. The possible toxic effects of these nanoparticles associated with human exposure are unknown. Many fine particles generally considered acquire unique surface properties, when engineered to nanosize and may exhibit toxic biological effects.^3,4 Nanoparticles and Nano formulations have already been applied as drug delivery system with great success. Nanoparticulate drug delivery systems have still greater potential for many applications, including anti- tumor therapy, gene therapy, and AIDS therapy, Radio therapy, in the delivery of proteins, antibiotics and vaccines and as vesicles to pass the blood brain barriers. Nanoparticles provides massive advantages regarding drug targeting, delivery and release with their additional potential to combine diagnosis and therapy, emerge as one of the major tools in nanomedicine.⁵ In this review article, highlight the possible toxic human health effects that can result from exposure to ultra fine particles (UFPs) generated by anthropogenic activities and their cardiopulmonary outcomes.

Keywords

Nanoparticles, Drug Delivery, Targeting, Drug Loading, Drug Release.

Full Text

     

Kevin C. Garala ¹, Anil J. Shinde ², Harinath N. More ¹

Affiliations
1 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, IN
2 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, IN

Abstract

In the present study we investigated the effect of generation 3 (G3) PAMAM dendrimer on the aqueous solubility of aceclofenac. The aqueous solubility of aceclofenac was measured in the presence of dendrimer. A 32 full factorial design was employed. The concentration of dendrimer and temperature were used as independent variables, while solubility of drug was selected as dependent variable. The experimental results showed that the aqueous solubility of aceclofenac was directly proportional to concentration of dendrimer and inversely proportional to the temperature under the experiment performed. Under the suitable condition, the solubility of aceclofenac can improves with the PAMAM dendrimer.

Keywords

Dendrimers, G3 PAMAM Dendrimer, 32 Full Factorial Design, Solubility Enhancement

Full Text